To assess changes in the overall neuronal densities in MS samples or a possible effect on the CUX2-positive population of projection neurons as previously reported by Schirmer et al.[40], we used the pan neuronal marker NEUN and the upper cortical layer marker CUX2 respectively (Online Resource Fig. 1s, t, w, x). The gene discussed is RBFOX3; the disease is myeloid sarcoma.