Recently, mutations in TTN have emerged as a major cause of both dominantly and recessively inherited myopathies covering a wide and still expanding spectrum (for review [8, 53]), including tibial muscular dystrophy (TMD) [21], limb girdle muscular dystrophy 2 J (LGMD2J) [21], hereditary myopathy with early respiratory failure (HMERF) [23, 24, 33, 38, 41, 57], Salih myopathy [4], centronuclear myopathy (CNM) [6], core myopathy with heart disease [7] and childhood-juvenile onset Emery-Dreifuss-like phenotype without cardiomyopathy [10]. The gene discussed is TTN; the disease is cardiomyopathy.