An animal study with mice without VWF showed, that these mice develop less atherosclerosis.8 A review from van Galen et al. gives a detailed overview over the results from different studies with animal models with VWF deficiency or blockage.10 These studies suggest that VWF deficiency may have a protective effect on atherosclerosis at arterial branch point predilection sites and on arterial thrombosis.10 This evidence concerns the gene VWF and atherosclerosis.