In terms of the cg05293407TRIM27 and smoking interaction, high methylation was associated with poor prognosis in NSCLC patients with medium–high pack‐year of smoking rather than low pack‐year of smoking, possibly because high activation of STAT3 and low expression of PTEN may only occur in patients with medium–high methylation of cg05293407TRIM27. This evidence concerns the gene PTEN and non-small cell lung carcinoma.