The relatively common p.R275W (c.823C > T, rs34424986) variant, the most frequent PD-associated variant in PRKN, has not been reported in the homozygous state and has only been reported in compound heterozygotes with another mutation in multiple AR PD families (MIM#602544), and it has been classified as likely pathogenic. The gene discussed is PRKN; the disease is Parkinson disease.