PRKN and Parkinson disease: Albeit non-significant, exome PD cases carrying single PRKN SNVs had lower AAO compared with non-carriers (average = 38.5 years vs. 43.1 years; Coeff = −4.34; 95% CI: −8.95, 0.28; P = 0.066), with carriers having significantly lower AAO in Reseq cases (average = 52.6 years vs. 60.5 years; Coeff = −7.84; 95% CI: −12.59, −3.09; P = 0.001).