Chopra et al. suggested that the molecular mechanism responsible for periodontitis aggravating CKD might be explained by periodontal pathogenic products, such as lipopolysaccharides, which activate Toll‐like receptors (TLRs) to produce pro‐inflammatory cytokines (IL‐6 and TNF‐α) that aggravate kidney tissue damage [23]. Here, TNF is linked to chronic kidney disease.