Depression was observed in S1 (red circles) and S1 in both aged WT (76.14 ± 3.02%, Wilcox test, p = 0.031; Figure 6c) and aged p75NTR KO (82.59 ± 3.04%, Wilcox test, p = 0.015; Figure 6d) mice, which were maintained throughout the entire recording period of 4 h. Here, NGFR is linked to major depressive disorder.