Three-dimensional scaffolds (2nd and 3rd generations) allow a continuous release of cytokines and growth factors enhancing mainly the first period of tissue repairs, such as TGF (transforming growth factors), PDGF (platelet-derived growth factors), VEGF (vascular endothelial growth factors), IGF (insulin-like growth factors), and many others, enhancing the healing process [3, 15], throughout almost 10 days [7] regulating the inflammation and reducing the risk of infection [20]. This evidence concerns the gene VEGFA and infection.