AGAP2-AS1 and breast cancer: Some of the HER2-associated lncRNAs identified to date includeZFAS1 which was found to associate with ribosomes in breast cancer cells16,17; HOX transcript antisense intergenic RNA(HOTAIR) which is involved in regulation of chromatin states and targets genes related to tumour metastasis and correlates with poor prognosis18,19; and AGAP2 antisense RNA 1 (AGAP2-AS1) which promotes resistance of breast cancer cells to trastuzumab through EV signalling20.