And TBX2 and TBX3 over-expressions has been elucidated to induce the tumor growth and metastasis, functioning as downstream target gene of Wnt/beta-catenin and pRb pathway through the suppression of p14ARF, p21CIP1, NDRG1 and E-cadherin [22, 23]. This evidence concerns the gene RB1 and neoplasm.