When TBX15 mRNA expression was entered into the proportional hazards model along with number of tumors (multiple), growth type (invasive), venous invasion (positive), and serum DCP levels (> 300 IU/L), low TBX15 mRNA expression in tumor tissue was identified as one of the independent predictors of poor prognosis (Table 3). This evidence concerns the gene TBX15 and neoplasm.