CHRNA7 and Alzheimer disease: Previous study reported that the cognitive deficits deteriorated in the APP-α7 KO animals when α7nAChR was absent, and the decreased α7nAChRs expression was associated with synaptic damage in AD patients (Pchitskaya et al., 2018); upregulation of α7nAChR expression was able to improve the cognitive deficits (Ma and Qian, 2019).