Rats in the T2DM group showed much higher numbers of adipocytes (Fig. 5B, D) and TRAP-positive osteoclasts (Fig. 5C, E) than those in the CON group (P < 0.05); however, genistein reduced both adipocyte and osteoclast numbers dose dependently (P < 0.05). Here, ACP5 is linked to type 2 diabetes mellitus.