Figure 1C and D shows that both FBG and AUC in the HF group were much higher than those in the CON group after STZ injection (P < 0.05). As for the fasting insulin levels, no significant difference was observed between the CON and HF groups (Fig. 1E); however, the HOMA-IR values in the HF group were significantly higher than those in the CON group (Fig. 1F). This evidence concerns the gene INS and hydrops fetalis.