CD8A and neoplasm: Previous studies have shown participation of HIF-1 in functional control of different immune cell subsets.25 Hypoxia-induced HIF-1 activation improves differentiation, proliferation and metabolic reprogramming of Th17 and Treg cells.22,26–28 The antitumor capacity of CD8 T cells is also increased by HIF-1 via induction of glycolytic metabolism, tumor infiltration and tumoricidal memory formation.29,30 Likewise, recent studies have shown participation of HIF-1 in the innate lymphoid compartment.