UC with symptoms of anxiety/depression had significantly higher Mayo scores [10 (8.5, 11) vs 8 (7, 9), p = 0.0017], higher UCEIS [6 (4.75, 7) vs 4 (3, 5), p < 0.0001], lower albumin levels [34.0 (28.2, 41.7) vs 40.1 (32.5, 44.0), p = 0.0070] and were more likely to undergo UC-related surgery (22.7% vs 5.3%, p = 0.0067). The gene discussed is ALB; the disease is major depressive disorder.