In addition to having a likely regulatory function on transcription and an eQTL effect of the expression of SH2B3 along with many other genes in our analysis, rs3184504 SNP has been also associated with a higher expression of SH2B3 in the intestinal mucosal of patients with active coeliac disease [38], islet autoimmunity [39] and also implicated with bacterial infections [40], making the 12q24/SH2B3 locus associations in our cohort interesting for further research. The gene discussed is SH2B3; the disease is celiac disease.