In the present study, the AUC values for discriminating each subgroup (normal, POAG, SOAG, and XFG) using LASSO regression ranged between 0.675 (POAG vs. normal) and 0.966 (XFG vs. normal) for the four variables used, and these values did not change significantly when only ATX or TGF-β3 was applied. Here, ENPP2 is linked to open-angle glaucoma.