The AUC values for distinguishing each subgroup (normal, POAG, SOAG, and XFG) using ATX, TGF-β1, TGF-β2, and TGF-β3 in LASSO regression ranged between 0.675 (POAG vs. normal) and 0.966 (XFG vs. normal). The gene discussed is ENPP2; the disease is open-angle glaucoma.