TGFB2 and open-angle glaucoma: As shown in Fig. 1A–D, ATX results in the present study are consistent with those of past reports4,26 including ours, in which we found that ATX was significantly upregulated in SOAG and XFG subjects, whereas TGF-β2 was significantly higher in POAG subjects but downregulated in SOAG and XFG subjects3.