PTPN11 and neoplasm: By using 4T1-sgPtpn11 syngeneic mouse model, we confirmed that the effect of SHP2 blockade on decreasing CD11b + myeloid cells was through direct targeting of myeloid lineage cells because SHP2 inhibition in tumor cells did not affect myeloid cells (Fig. 8b and Supplementary Fig. 9e,f).