PTPN11 and neoplasm: Both SHP099 and TNO155 upregulated CXCL10 secretion upon rhIFNγ treatment (Fig. 4b and Supplementary Fig. 6c); in addition, SHP2 blockade lowered the dose of rhIFNγ required to affect OVCAR-8 cell viability, indicating that SHP2 inhibition sensitized tumor spheroids to IFNγ (Fig. 4c and supplementary Fig. 6d).