CD8A and neoplasm: We propose that this is achieved by: (a) amplifying IFNγ signaling in cancer cells54; (b) enhancing chemoattractant cytokine secretion by cancer cells which may recruit anti-tumor lymphocytes to the tumor; (c) increasing antigen presentation by cancer cells; (d) positively regulating CD8 T cell proliferation and function; (e) inhibiting the function of immunosuppressive myeloid cells on anti-tumor T cells.