In addition, SHP2 inhibition increased expression of CXCR3 ligands, CXCL9 and CXCL10, in MIA PaCa-2-PBMCs co-culture, suggesting that upregulation of chemoattractant cytokines by inhibition of SHP2 may be a common phenotype in the tumor microenvironment (Supplementary Fig. 5b). Here, PTPN11 is linked to neoplasm.