We found that treatment with SHP099 led to increased expression of three CXCR3 ligands, the chemoattractant cytokines CXCL9, CXCL10 and CXCL11 specifically in tumor cells in co-culture, with CXCL10 showing the most significant upregulation and magnitude of expression (Fig. 3a,b). The gene discussed is CXCL9; the disease is neoplasm.