Strikingly, a large proportion of the IFNγ signature genes were upregulated by SHP2 inhibition specifically in tumor cells in co-culture, including cytokines (CXCL9, CXCL10, CXCL11 and CCL5) and antigen presenting machinery (HLA-A, HLA-B and B2M) (Fig. 4a). This evidence concerns the gene B2M and neoplasm.