PTPN11 and neoplasm: Unlike in the 4T1 model, SHP2 inhibition alone did not enhance tumor infiltrated CD8+ T cells in MC38 syngeneic model (Fig. 9d), which suggests that targeting tumor intrinsic signaling contributed to CD8+ T cell recruitment to the tumor microenvironment, in consideration that MC38 is SHP2 inhibitor-insensitive.