In the logistic regression analysis, the levels of IL-6 [odds ratio (OR) 1.001; 95% confidence interval (CI) 1.000–1.001; P = 0.010], NT-proBNP (OR 1.000; 95% CI 1.000–1.000; P = 0.013), and INR (OR 1.917; 95% CI 0.949–3.871; P = 0.046) within the first 24 h of admission were independently associated with 28-day mortality of sepsis (Table 3), and were valuable for predicting 28-day mortality. Here, IL6 is linked to Sepsis.