The rate of MYC escape (kesc), however, differed by several log orders between mice in the same treatment group (e.g., ranging from 3.41 × 10–11 to 2.18 × 10–7 day−1 in Supplementary Table 10), suggesting a mutation event occurring in as few as 20 million cells per day and a diverse mutation frequency even in cancers initiated by a single clonal population of cells in genetically identical subjects (Fig. 3a). This evidence concerns the gene MYC and cancer.