MED15 and cancer: Amplified DNA segments localizing oncogenes such as activating transcription factor 2 (ATF2)34, TTN antisense RNA 1 (TTN-AS1)35, zinc fingers and homeoboxes 2 (ZHX2)36, Derlin-1 (DERL1)37, mediator complex subunit 15 (MED15)38, and MYC proto-oncogene (MYC)39 (Supplemental Tables S5–S7), which have been reported to mediate drug resistance in multiple cancer types.