MYC and esophageal squamous cell carcinoma: In summary, genomic and transcriptomic profiling revealed that activation of mTORC1, MAPK, and c-Myc signaling was associated with adaptive resistance to CYH33 in ESCC cells, and combination of CYH33 and RAD001, MEK162, or OTX015 demonstrated synergistic activity against these resistant cells.