MAPT and Alzheimer disease: To assess whether changes in the expression level of these modules may contribute to the effect of sex on AD and AD endophenotypes, we included the module information in a regression model and found that m114 explains 39% of the variance in amyloid pathology that is explained by sex, and m5 explains 13% of the variance in Tau pathology that is explained by sex (Supplementary Fig. 7a, b).