Surveying the 4158 TMEM119+ cells captured from cortical tissue sections of six subjects obtained from Rush Alzheimer’s Disease Center, we find that TMEM119 + VASP + microglia are less ramified than TMEM119 + VASP− cells (P = 3 × 10-8, β = −0.26) (Fig. 4b). The gene discussed is TMEM119; the disease is early-onset autosomal dominant Alzheimer disease.