Our multivariate modeling prunes the modest associations (Fig. 2a, b) that may be driven by correlations amongst modules and traits and prioritizes the strongest associations in our data: we clearly see that m113 and m114 are associated with β-amyloid pathology which typically accumulates early in the asymptomatic and early symptomatic phase of AD, and they are not directly associated with tau pathology. Here, MAPT is linked to Alzheimer disease.