The NZM2328 mouse model deficient in STAT4 had reduced autoantibody production but increased kidney disease and mortality, whereas STAT4 deficiency in the SLE 1,2,3 triple congenic model resulted in reduced responses in various autoimmune parameters such as autoantibody production, kidney disease, and mortality (34, 35). The gene discussed is STAT4; the disease is systemic lupus erythematosus.