Diabetic nephropathy (DN), defined by low estimated glomerular filtration rate (< 60 mL/min/1.73 m2 for 3 months or more) or albuminuria (urinary albumin-to-creatinine ratio ≥ 30 mg/g) in the setting of DM [2], is one of the most serious complications of DM. The gene discussed is ALB; the disease is diabetes mellitus.