GBA1 and Parkinson disease: Severe GBA mutations such as c.115 + 1 G > A (IVS2 + 1), c.84dupG (84GG), c.1297 G > T (V394L), c.1263del + RecTL, c.1342 G > C (D409H), and c.1448 T > C (L444P), appear to be correlated with a higher risk of PD development compared to the mild mutations such as c.84dupG (84GGG) and N370S [58].