To further determine whether increase of STOML2 in lenvatinib treatment is HIF-1α dependent, we examined STOML2 expression in HCC cells with HIF-1α downregulation and found that lenvatinib-induced STOML2 upregulation was abrogated upon silencing HIF-1α in both SMMC-7721 and HCCLM3 (Fig. 6b). The gene discussed is STOML2; the disease is hepatocellular carcinoma.