Specific to skeletal dysplasia, pathogenic variants in genes encoding type II and XI collagen (COL2A1, COL11A1 and COL11A2), Filamin-A (FLNA), and the diastrophic sulfate transport protein (SLC26A2) are all well-known as being associated with cleft palate. The gene discussed is COL11A1; the disease is cleft palate.