The proportion of total effect mediated through Hb level was highest for SCD-HAZ association (adjusted proportion mediated 0.928; 95% CI 0.535, 2.770), implying that the effect of SCD on HAZ was decomposed into two parts: nearly 93% of the total effect was indirect, i.e., mediated through Hb level and approximately 7% was direct effect (Table 4). The gene discussed is GSTM1; the disease is Schnyder corneal dystrophy.