Among RA-SLE-ADR network, the key targets with higher degree including IL6 (Interleukin-6 receptor), STAT3 (Signal transducers and activators of transcription30, TNF (Tumor necrosis factor), VEGFA (Vascular endothelial growth factor), TP53 (Cellular tumor antigen p53), MMP9 (Matrix metalloprotein 9). The gene discussed is STAT3; the disease is rheumatoid arthritis.