Among RA-SLE-ADR network, the key targets with higher degree including IL6 (Interleukin-6 receptor), STAT3 (Signal transducers and activators of transcription30, TNF (Tumor necrosis factor), VEGFA (Vascular endothelial growth factor), TP53 (Cellular tumor antigen p53), MMP9 (Matrix metalloprotein 9). This evidence concerns the gene IL6R and systemic lupus erythematosus.