ESRRG and thyroid gland undifferentiated (anaplastic) carcinoma: For example, one ERRγ reverse agonist is a tetrasubstituted olefin analog that enhances the function of sodium iodide transporters in anaplastic thyroid cancer cells, thereby promoting the response to radioactive iodine treatment in vitro, and can be used as a potential therapeutic agent for ERRγ-mediated cancers (Kim et al. 2019b).