The level of sIL-23 R in the plasma was also detected using ELISA, and the results revealed that its level was significantly down-regulated in pSS patients than in NCs (Figure 5d), and a positive correlation was observed between the level of sIL-23 R and the MFI of AMAD17 in CD4+ T cells (r = 0.582, p < 0.001). This evidence concerns the gene CD4 and peeling skin syndrome.