ADAM17 and peeling skin syndrome: To explore the relationship between miR-146a-5p and ADAM17 in pSS patients, miR-146a-5p inhibitor was transfected into pSS patient-derived PBMCs, and the results showed that the inhibition of endogenous miR-146a-5p significantly up-regulated the protein and mRNA expression of ADAM17 (Figure 4a).