Indeed, interaction between SARS-CoV-2 and ACE2 was proposed as a potential mechanism for the entry of SARS-CoV-2 into the cell [17], and the administration of ACEIs and ARBs upregulated ACE2 expression and activity in several experimental studies [3-5], implying that patients on ACEIs or ARBs may theoretically be exposed to a greater risk from COVID-19. Here, ACE2 is linked to COVID-19.