NPC1 and neurodegenerative disease: Although currently only one publication, by Jürs and colleagues [45], has analyzed OS in iPSC-derived neuronal cells, we will briefly summarize the results obtained with other NPC1 model systems, as the restoration of mitochondrial function and the improvement of OS are discussed as possible targets for the treatment of neurodegenerative diseases (for review see, e.g., [79,80]).