In a del(5q) MDS model, Rps14 haploinsufficiency has been linked to increased innate immune responses and to a p53-dependent erythroid differentiation defect, and the heterozygous deletion of another ribosomal protein, Rps6, induces a DBA phenotype in a mouse model that can be rescued by inactivating p53 [134]. This evidence concerns the gene RPS6 and Diamond-Blackfan anemia.