Therefore, diagnostic and pathophysiologic overlaps among BMF syndromes might be translated into cytokine profiling similarities because several cytokines can be found to be augmented in different BMF syndromes, such as IL-1ra and IL-6, which can be increased in both hMDS and T-LGL leukemia, or IFN-γ, which is a common proinflammatory mediator involved in immune response polarization and BM growth inhibition. This evidence concerns the gene IFNG and T-cell large granular lymphocyte leukemia.