In addition, circulating levels of IFN-α2, IFN-γ, monocyte chemoattractant protein-1, epidermal growth factor, IL-6, IL-8, IL-10, IL-1β, IL-12p35, IL-1Ra, and MIP1-a are increased in the sera of LGL leukemia patients (Table 3) [104,105]. Here, IL6 is linked to T-cell large granular lymphocyte leukemia.