These include insulin-like growth factor-1 (IGF-1), fibroblast growth factor-2, IL-6, IL-15, myostatin, osteoglycin, irisin, and osteoactivin, which have been initially implicated in the pathogenesis of sarcopenia but appear to also be regulators of bone remodeling and thus potentially relevant for osteoporosis [16,17,18,19,20,21,22]. The gene discussed is IGF1; the disease is osteoporosis.