INS and Hyperglycemia: Hyperglycemia-dysregulated miRNAs affect insulin sensitive tissues by regulating molecules of insulin signaling pathway (e.g., Irs1, Irs2, Akt, Pten, Glut4, mTOR), inflammation (e.g., Tlr4, NfκB, IKK-β, IL−6), lipid metabolism (e.g., Sirt1), prooxidant (e.g., Nox) and antioxidant genes (e.g., Sod1, Nrf2, FoxO) and more [9].