In a mouse model for human CLL, the B cell-restricted expression of ROR1 accelerated leukemogenesis through an interaction of ROR1 with the T cell leukemia 1 (TCL1) oncogene, which activated pro-survival signaling via the protein kinase AKT and resulted in leukemia cell proliferation and resistance to apoptosis [85]. This evidence concerns the gene WEE1 and B-cell chronic lymphocytic leukemia.