ROR1 and lung cancer: Blockade of ROR1 in lung cancer cells was found to suppress expression of CDK4 and CCNE1, two important cell cycle regulators, as well as Bcl-XL and Bcl-2, two critical anti-apoptotic factors, while it increased the expression of several pro-apoptotic factors including Bak, caspase-3, and caspase-7 [87].