Although non-canonical WNT signaling has so far mainly been described to occur primarily via signaling cascades at the protein level, overexpression of ROR2 in MCF-7 breast cancer cells resulted in large changes at the transcriptomic level with more than 2860 differentially expressed genes (e.g., FAT1, VIL1, HNF4G, WIPF1). Here, ROR2 is linked to breast cancer.