Firstly, WNT/ROR1 signaling was identified as a rescue pathway that can induce nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), and MEK/extracellular-signal-regulated kinase (ERK) activation independent of B cell receptor (BCR)/Bruton tyrosine kinase (BTK) in CLL and MCL [18,106,107]. Here, AKT1 is linked to B-cell chronic lymphocytic leukemia.