Activation of ROR1 and ROR2 was shown to result in the phosphorylation of PI3K, AKT, cAMP response element-binding protein (CREB), and mTOR as well as its downstream targets S6 and 4EBP1 in numerous tumor entities [18,22,40,41,44,56,70,151,158,159]. This evidence concerns the gene ROR2 and neoplasm.