In line with this, transcriptomic analyses of ROR1-expressing patient-derived CLL cells revealed a gene expression signature associated with protein kinase activation, AKT-related signaling factors and proliferation, while ROR1-negative CLL cells were characterized by subnetworks associated with apoptosis and consequential RNA processing and decay [36]. The gene discussed is WEE1; the disease is B-cell chronic lymphocytic leukemia.