Another study obtained from KrasG12D-driven murine NSCLC model showed that, opposite to Hif-1α, Hif-2α deletion resulted in increased tumor burden that correlated with reduced expression of the candidate tumor suppressor gene Scgb3a1 (HIN-1, Secretoglobin Family 3A Member 1) [49]. The gene discussed is EPAS1; the disease is non-small cell lung carcinoma.