It should be noted that Parkinson’s disease is also associated with mutations in the genes of nuclear genome (SNCA (PARK1), PARK2, PINK1 (PARK6), DJ-1 (PARK7), LRRK2 (PARK8), ATP13A2 (PARK9), PLA2G6 (PARK14), FBXO7 (PARK15), VPS35 (PARK17), EIF4G1 (PARK18), COQ2, DNAJC6, ATP6AP2, SYNJ1, DNAJC13), which lead to oxidative stress, apoptosis or stress in the endoplasmic reticulum [58,59,60,61,62]. Here, PRKN is linked to Parkinson disease.