ACE2 and Hypertension: In Drosophila, the hnRNP F homolog, Glorund was also shown to recognizes poly(G) sequences to regulate alternative splicing, implying that alternative splicing events are conserved in both human and Drosophila. Overexpression of hnRNP F enhanced Ace-2 gene transcription, avoids TGF-β1 inhibition of Ace-2 gene transcription, prevents hypertension and kidney injury in diabetes [22].