Moreover, YAP/TAZ are mechanoregulators that bind to Smad transcription factors, the central mediators of TGF-β elicited profibrotic responses in fibroblasts, suggesting that TGF-β may induce renal fibrosis in a YAP/TAZ- and Smad2/3-dependent manner [29]. The gene discussed is YAP1; the disease is renal fibrosis.