Thus, we posited that HDACi could restore SPCA2 expression in TNBC (Figure 2A) and evaluated the effect of the pan-HDACi vorinostat and the class I HDACi romidepsin [30] on SPCA2 expression in the metastatic breast cancer cell lines, MDA-MB-231 and Hs578T. This evidence concerns the gene ATP2C2 and breast cancer.