Given that BK was recently reported to inhibit type I IFN responses induced by TLR7 and TLR9 ligands in vivo (normal and lupus-prone mice) and in vitro (human PBMCs) via reduced expression of ISGs and STAT2 phosphorylation [60], we next asked whether BK increased DENV replication in HBMECs by modulating the antiviral type-1 IFN pathway. This evidence concerns the gene TLR9 and systemic lupus erythematosus.