Moreover, TBX3, which was also identified as a downstream target of the Wnt pathway and a pivotal mediator of β-catenin-dependent proliferation and survival in liver tumorigenesis [91], was also found to be upregulated in breast cancer where it represses ARF expression by interacting with histone deacetylases [92]. The gene discussed is CDKN2A; the disease is breast carcinoma.