The Korean Society of Pediatric Endocrinology’s Clinical Guidelines for precocious puberty recommend the consecutive measurement of LH at intervals of 15–30 min from basal conditions to 90 to 120 min after the application of a standard dose of LHRH (100 μg) via injection for GnRH stimulation [8]. The gene discussed is GNRH1; the disease is precocious puberty.