For example, the DNA base excision repair glycosylase enzyme NEI-like protein 1 (NEIL1), encoding antizyme inhibitor 1 (AZIN1), Ras homologue family member Q (RHOQ), and protein tyrosine phosphatase non-receptor type 6 (PTPN6) are found hyper-edited in cancer compared to healthy tissues, while gamma-aminobutyric acid type A receptor alpha 3 subunit (Gabra3), glutamate receptor subunit B Glur-B (also known as GRIA2), and insulin-like growth factor-binding protein 7 (IGFBP7) are found to be hypo-edited in cancer compared to normal tissue. The gene discussed is IGFBP7; the disease is cancer.