Additionally, ADAMTS-4 expression in women with and without PCOS was remarkably correlated with total progesterone and progesterone receptor B (PRB) (r = 0.6, p < 0.0001, Figure 3b and r = 0.42, p < 0.0001, Figure 3c, respectively). The gene discussed is RB1; the disease is polycystic ovary syndrome.