The principal reasons behind selecting the BMM are: (i) it models the macroscopic response of the complex glucose‐insulin dynamics via a simple nonlinearity with an acceptable degree of accuracy [8 ], (ii) it has a very high applicability in ‘bed‐side AP’ [9 ] that is crucial for the treatment of T1D patients with diabetes ketoacidosis and in the intensive care unit (ICU) [10 ] and (iii) important physiological factors like, glucose effectiveness, insulin sensitivity and insulin degradation rate can be easily modelled in terms of its parameters [8 ]. Here, INS is linked to diabetes mellitus.