In contrast, genetic prion disease caused by GPI-anchorless near full-length PrPSc (Q226X) [15] is characterized by a rapid disease course and vascular amyloid, similar to the rapid course and vascular amyloid observed in the prion-infected GPI-anchorless PrP-expressing mice [12], illustrating how the length of the aggregating protein impacts the disease course and cellular targets. Here, PRNP is linked to prion disease.