The results of adding information on PRSs were broadly similar to those observed overall in analyses that included (1) information on body-mass index, family history of CVD, use of blood-pressure-lowering treatment, or CRP in the prediction model (S4 Table; S8 Fig); (2) participants receiving lipid-lowering treatment at baseline (S5 Table; S9 Fig); (3) use of PRSs derived for the composite CVD outcome or for all stroke (S6 Table); and (4) a broader definition of the CVD outcome (i.e., CHD, stroke, PTCA, or CABG; S9 Fig). Here, CRP is linked to Stroke.