Of these 7 nodes, the most significant differences between RA and HC were in co-stimulation with GM-CSF and IL-2 using p-STAT5 for readout (p = 2.27 x 10−21, p = 2.14 x10-7 and p < 0.0001in Cohort 1, T6M and TT0, respectively) (Fig 1D, and S4B Fig). The gene discussed is IL2; the disease is rheumatoid arthritis.