In a pressure‐overload heart, a model for inducing dilated cardiomyopathy, Bodiga et al and Patel et al reported that loss of the ACE2 gene led to increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and fibrosis, accompanied by up‐regulated NADPH oxidase 2 (NOX2), p47phox, MMP2 and MMP9. This evidence concerns the gene CYBB and dilated cardiomyopathy.